But when I put my bet on her
Little miss snake eyes ruined my life

from Bruno Mars – Natalie Lyrics on Rap Genius

Meaning

Fitting in with the previous lines and the gambling, he’s taking a chance with Natalie and betting that she’s a winner.

Also in a game of dice getting snake eyes typically results in a loss and has become a term referring to bad luck.

Snake eyes have also been associated with people who possess traits of dishonesty, betrayal and treachery. Qualities which Natalie seems to have.

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