In an interview, Matthew Bellamy explained:

The song… I wrote the song… I couldn’t decide if I wanted to like, do music or go to university or something. So I sort of left the band for about four months when I was about 18 and went and learned loads of Spanish guitar and Greek guitar. I spent a long time travelling round Europe and you know… I learnt stuff and I wrote that song in Greece. It’s about… I was reading a book at the time about like cyber-culture you know? This was around the time when cyber-culture was looking like a really big thing and the future – about how we’re going to leave the body behind and the ideals of the mind, and like how it’s replacing religion and all this you know? And how we’re trying to connect each other through the Internet and stuff, and try and make our own heaven because, you know, religion didn’t really bring it to us – it’s sort of about that. And the songs about how people don’t really face up to their inner emotions a lot of the time and they just get on with their mundane life.

In most dictionaries, the words muscle and museum come before and after, respectively, the word muse.